BDBM50114549 CHEMBL3608365

SMILES CC(C)[C@H]1C2=C(Oc3c1c(O)cc(O)c3C(=O)C(C)C)C(C)(C)C(=O)C(C)(C)C2=O

InChI Key InChIKey=AYAUOXWJIWVPSO-CQSZACIVSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50114549   

TargetProstaglandin E synthase(Homo sapiens (Human))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50114549(CHEMBL3608365)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of mPGES-1 in microsomal membranes isolated from interleukin-1beta-stimulated human A549 cells using PGH2 as substrate assessed as PGE2 fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50114549(CHEMBL3608365)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-LO in ionophore A23187-stimulated human PMNL using arachidonic acid as substrate assessed as formation of LTB4, 5(S),12(S)-DiHETE, 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Jena

Curated by ChEMBL
LigandPNGBDBM50114549(CHEMBL3608365)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as formation of all-trans isomer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed