BDBM50116833 CHEMBL3612923

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC(O)c2ncc(cc2Cl)C#N)CC1

InChI Key InChIKey=TZVGCXFECRFDTR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50116833   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116833(CHEMBL3612923)
Affinity DataIC50: 340nMAssay Description:Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116833(CHEMBL3612923)
Affinity DataIC50: 340nMAssay Description:Inhibition of ROMK (unknown origin) expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116833(CHEMBL3612923)
Affinity DataIC50: 5.70E+3nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50116833(CHEMBL3612923)
Affinity DataIC50: 5.70E+3nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed