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BDBM50116902 CHEMBL3613026

SMILES: CC(=O)Oc1ccc(\C=C\C(=O)OCCCCCCCCC#C)cc1OC(C)=O

InChI Key: InChIKey=OUSGGHVJIJZOQD-FYWRMAATSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50116902   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50116902
PNG
(CHEMBL3613026)
Show SMILES CC(=O)Oc1ccc(\C=C\C(=O)OCCCCCCCCC#C)cc1OC(C)=O
Show InChI InChI=1S/C23H28O6/c1-4-5-6-7-8-9-10-11-16-27-23(26)15-13-20-12-14-21(28-18(2)24)22(17-20)29-19(3)25/h1,12-15,17H,5-11,16H2,2-3H3/b15-13+
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Ferrara

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in human neutrophils assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 15 mins before A23187 and arachidon...


Eur J Med Chem 101: 573-83 (2015)


Article DOI: 10.1016/j.ejmech.2015.07.011
BindingDB Entry DOI: 10.7270/Q2V69MDP
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50116902
PNG
(CHEMBL3613026)
Show SMILES CC(=O)Oc1ccc(\C=C\C(=O)OCCCCCCCCC#C)cc1OC(C)=O
Show InChI InChI=1S/C23H28O6/c1-4-5-6-7-8-9-10-11-16-27-23(26)15-13-20-12-14-21(28-18(2)24)22(17-20)29-19(3)25/h1,12-15,17H,5-11,16H2,2-3H3/b15-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



University of Ferrara

Curated by ChEMBL


Assay Description
Inhibition of human 5-LOX expressed in Escherichia coli Bl21 (DE3) assessed as reduction in LTB4 and 5-H(P)ETE) formation pre-incubated for 10 mins b...


Eur J Med Chem 101: 573-83 (2015)


Article DOI: 10.1016/j.ejmech.2015.07.011
BindingDB Entry DOI: 10.7270/Q2V69MDP
More data for this
Ligand-Target Pair