BindingDB PrimarySearch

BDBM50117922 (1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate::2-{2-[3-(1H-benzoimidazol-2-yl)-propylamino]-ethyl}-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester(Mibefradil)Methoxy-acetic acid::CHEMBL45816::MIBEFRADIL::Methoxy-acetic acid (1S,2S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester::Methoxy-acetic acid 2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester::Mibefradil dihydrochloride

SMILES: CC(C)[C@H]1c2ccc(cc2CC[C@@]1(CCN(C)CCCc3[nH]c4ccccc4n3)OC(=O)COC)F

InChI Key: InChIKey=HBNPJJILLOYFJU-UHFFFAOYSA-N

Data: 4 KI 75 IC50 1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 80 hits for monomerid = 50117922
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1H (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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ATP-dependent translocase ABCB1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Mouse)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Mouse)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium channel subfamily K member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	500	n/a	n/a	7.3	22
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
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Calcium release-activated calcium channel protein 1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Calcium release-activated calcium channel protein 1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1H (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	202	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 7 subunit alpha (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1H (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Human)	BDBM50117922 (CHEMBL45816 \| Methoxy-acetic acid 2-(2-{[3-(1H-ben...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
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