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BDBM50117986 (6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl)-phenyl]-amine::CHEMBL125920

SMILES: CCOc1cc2ncnc(Nc3cccc(c3)-c3cc[nH]n3)c2cc1OCC

InChI Key: InChIKey=KQEIKIGFBVHSFM-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50117986   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50117986
PNG
((6,7-Diethoxy-quinazolin-4-yl)-[3-(1H-pyrazol-3-yl...)
Show SMILES CCOc1cc2ncnc(Nc3cccc(c3)-c3cc[nH]n3)c2cc1OCC
Show InChI InChI=1S/C21H21N5O2/c1-3-27-19-11-16-18(12-20(19)28-4-2)22-13-23-21(16)25-15-7-5-6-14(10-15)17-8-9-24-26-17/h5-13H,3-4H2,1-2H3,(H,24,26)(H,22,23,25)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinase


J Med Chem 45: 3865-77 (2002)


Article DOI: 10.1021/jm010496a
BindingDB Entry DOI: 10.7270/Q2PN94Z0
More data for this
Ligand-Target Pair