BDBM50118696 5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-2-fluoro-benzonitrile::5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-2-fluorobenzonitrile::CHEMBL136721

SMILES CC1(C)OC(=O)Nc2ccc(cc12)-c1ccc(F)c(c1)C#N

InChI Key InChIKey=QYXWQJJMCRIUKE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50118696   

TargetProgesterone receptor(Human)
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118696(5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118696(5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]...)
Affinity DataIC50: 15.1nMAssay Description:Antagonist activity at progesterone receptor expressed in T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118696(5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]...)
Affinity DataIC50: 15.1nMAssay Description:Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Women'S Health Research Institute

Curated by ChEMBL
LigandPNGBDBM50118696(5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]...)
Affinity DataIC50: 55nMAssay Description:Antagonist activity against progesterone receptor (PR) in an assay using PRE-luciferase plasmid co-transfected CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed