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BDBM50118844 (2-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-ylmethyl]-amine::CHEMBL424104

SMILES: COc1cc2ncnc(N3CCN(CC3)C(NCc3ccccc3Cl)=NC#N)c2cc1OC

InChI Key: InChIKey=BLMKQJNQUNDICW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118844   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50118844
PNG
((2-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dime...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccccc3Cl)=NC#N)c2cc1OC
Show InChI InChI=1S/C23H24ClN7O2/c1-32-20-11-17-19(12-21(20)33-2)28-15-29-22(17)30-7-9-31(10-8-30)23(27-14-25)26-13-16-5-3-4-6-18(16)24/h3-6,11-12,15H,7-10,13H2,1-2H3,(H,26,27)
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Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)


Article DOI: 10.1021/jm0201114
BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair