BDBM50118877 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (benzo[1,3]dioxol-5-ylmethyl)-amide::CHEMBL139729

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc4OCOc4c3)c2cc1OC

InChI Key: InChIKey=BSUJJRBKMDRXHZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PDGFR-beta/Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50118877 (4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...) Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc4OCOc4c3)c2cc1OC Show InChI InChI=1S/C23H25N5O5/c1-30-19-10-16-17(11-20(19)31-2)25-13-26-22(16)27-5-7-28(8-6-27)23(29)24-12-15-3-4-18-21(9-15)33-14-32-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL					Assay Description Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...				J Med Chem 45: 4513-23 (2002) Article DOI: 10.1021/jm0201114 BindingDB Entry DOI: 10.7270/Q2JH3MXF
					More data for this Ligand-Target Pair