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BDBM50118877 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (benzo[1,3]dioxol-5-ylmethyl)-amide::CHEMBL139729

SMILES: COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc4OCOc4c3)c2cc1OC

InChI Key: InChIKey=BSUJJRBKMDRXHZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118877   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50118877
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O5/c1-30-19-10-16-17(11-20(19)31-2)25-13-26-22(16)27-5-7-28(8-6-27)23(29)24-12-15-3-4-18-21(9-15)33-14-32-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,29)
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Similars

Article
PubMed
n/an/a 1.87E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)


Article DOI: 10.1021/jm0201114
BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair