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BDBM50118918 CHEMBL139770::{2-[2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbonyl]-phenyl}-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-methanone

SMILES: O=C(C1CCCN1C(=O)c1ccccc1C(=O)N1CCC[C@H]1C(=O)N1CCCC1)N1CCCC1

InChI Key: InChIKey=HQDSTBZJFIXHNG-HMTLIYDFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50118918   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Sus scrofa)
BDBM50118918
PNG
(CHEMBL139770 | {2-[2-(Pyrrolidine-1-carbonyl)-pyrr...)
Show SMILES O=C(C1CCCN1C(=O)c1ccccc1C(=O)N1CCC[C@H]1C(=O)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C26H34N4O4/c31-23(29-17-7-11-21(29)25(33)27-13-3-4-14-27)19-9-1-2-10-20(19)24(32)30-18-8-12-22(30)26(34)28-15-5-6-16-28/h1-2,9-10,21-22H,3-8,11-18H2/t21-,22?/m0/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pig brain ;value ranges from (7800-54000)


J Med Chem 45: 4581-4 (2002)


Article DOI: 10.1021/jm020966g
BindingDB Entry DOI: 10.7270/Q22R3R02
More data for this
Ligand-Target Pair