BDBM50119620 CHEMBL3618244

SMILES COc1ccc(Nc2nc3ccc(cn3c2-c2nc(C)nc(N)n2)C(C)(C)O)cn1

InChI Key InChIKey=ULORBRZRLVUXSS-VMNVEMLISA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50119620   

LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataKi:  26nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataIC50:  45nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50119620(CHEMBL3618244)
Affinity DataIC50:  36nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed