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BDBM50120105 (2-Chloro-6-methyl-phenyl)-(7-piperazin-1-yl-imidazo[1,5-a]quinoxalin-4-yl)-amine::CHEMBL106822::N-(2-chloro-6-methylphenyl)-7-(piperazin-1-yl)imidazo[1,5-a]quinoxalin-4-amine

SMILES: Cc1cccc(Cl)c1Nc1nc2cc(ccc2n2cncc12)N1CCNCC1

InChI Key: InChIKey=JOFVPPUTQXWTRV-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50120105   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (Human))
BDBM50120105
PNG
((2-Chloro-6-methyl-phenyl)-(7-piperazin-1-yl-imida...)
Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(ccc2n2cncc12)N1CCNCC1
Show InChI InChI=1S/C21H21ClN6/c1-14-3-2-4-16(22)20(14)26-21-19-12-24-13-28(19)18-6-5-15(11-17(18)25-21)27-9-7-23-8-10-27/h2-6,11-13,23H,7-10H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



University of Zurich

Curated by ChEMBL


Assay Description
Inhibition of Lck


J Med Chem 51: 1179-88 (2008)


Article DOI: 10.1021/jm070654j
BindingDB Entry DOI: 10.7270/Q29Z95RD
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50120105
PNG
((2-Chloro-6-methyl-phenyl)-(7-piperazin-1-yl-imida...)
Show SMILES Cc1cccc(Cl)c1Nc1nc2cc(ccc2n2cncc12)N1CCNCC1
Show InChI InChI=1S/C21H21ClN6/c1-14-3-2-4-16(22)20(14)26-21-19-12-24-13-28(19)18-6-5-15(11-17(18)25-21)27-9-7-23-8-10-27/h2-6,11-13,23H,7-10H2,1H3,(H,25,26)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
50% inhibition of the phosphorylation of an exogenous substrate by human Lck enzyme.


Bioorg Med Chem Lett 12: 3153-6 (2002)


Article DOI: 10.1016/s0960-894x(02)00677-7
BindingDB Entry DOI: 10.7270/Q2NC60JR
More data for this
Ligand-Target Pair