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BDBM50120169 C-[(R)-C-{(S)-1-[Bis-(3-trifluoromethyl-phenyl)-methyl]-azetidin-2-yl}-C-(3-chloro-phenyl)]-methylamine::CHEMBL320061

SMILES: N[C@@H]([C@@H]1CCN1C(c1cccc(c1)C(F)(F)F)c1cccc(c1)C(F)(F)F)c1cccc(Cl)c1

InChI Key: InChIKey=MZJLFDPTAQVJLX-FCHUYYIVSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50120169   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120169
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-trifluoromethyl-phenyl)-me...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(c1)C(F)(F)F)c1cccc(c1)C(F)(F)F)c1cccc(Cl)c1
Show InChI InChI=1S/C25H21ClF6N2/c26-20-9-3-4-15(14-20)22(33)21-10-11-34(21)23(16-5-1-7-18(12-16)24(27,28)29)17-6-2-8-19(13-17)25(30,31)32/h1-9,12-14,21-23H,10-11,33H2/t21-,22+/m0/s1
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Similars

Article
PubMed
2.59E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)


Article DOI: 10.1016/s0960-894x(02)00652-2
BindingDB Entry DOI: 10.7270/Q2KK9C9R
More data for this
Ligand-Target Pair