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BDBM50120378 CHEMBL3616709

SMILES: Nc1c(Cl)cc(cc1Cl)C(=O)NC1C2CC3CC(C2)CC1C3

InChI Key: InChIKey=ZPQULEGVXQBGON-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50120378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50120378
PNG
(CHEMBL3616709)
Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C17H20Cl2N2O/c18-13-6-12(7-14(19)15(13)20)17(22)21-16-10-2-8-1-9(4-10)5-11(16)3-8/h6-11,16H,1-5,20H2,(H,21,22)
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Similars

Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human mixed sex human liver microsomes assessed as reduction in conversion of [3H]-cortisone to [3H]-cortisol pre-incuba...


Bioorg Med Chem Lett 25: 4250-3 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.097
BindingDB Entry DOI: 10.7270/Q2ZP47Z5
More data for this
Ligand-Target Pair