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BDBM50120917 CHEMBL3356074

SMILES: COc1cccc2C(=O)N=C(NCC(C)(C)c3ccccc3)c12

InChI Key: InChIKey=WVNWIKASGFTXTN-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50120917   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv1.5


(Homo sapiens (Human))
BDBM50120917
PNG
(CHEMBL3356074)
Show SMILES COc1cccc2C(=O)N=C(NCC(C)(C)c3ccccc3)c12
Show InChI InChI=1S/C19H20N2O2/c1-19(2,13-8-5-4-6-9-13)12-20-17-16-14(18(22)21-17)10-7-11-15(16)23-3/h4-11H,12H2,1-3H3,(H,20,21,22)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human KV1.5 expressed in mouse L929 cells assessed as decrease in ultrarapid potassium current amplitude


Bioorg Med Chem Lett 25: 4983-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.066
BindingDB Entry DOI: 10.7270/Q2HH6MWT
More data for this
Ligand-Target Pair