BDBM50121345 CHEMBL3622104::US9751881, Example 1

SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CN(C(=O)C2)c2ccc(cn2)C#N)CC1

InChI Key InChIKey=WOQONCRZLPNXNO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121345   

LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50: 10.5nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Kir1.1 expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121345(CHEMBL3622104 | US9751881, Example 1)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2019
Entry Details Article
PubMed