BDBM50121902 CHEMBL287630::[(S)-1-((2S,3R)-2-Benzenesulfonyl-4-oxo-azetidin-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester

SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@H]1[C@@H](NC1=O)S(=O)(=O)c1ccccc1)OCc1ccccc1

InChI Key InChIKey=JICMCJAFBMCIIX-FBLLAGFSSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121902   

TargetCathepsin B(Rattus norvegicus)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121902(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Affinity DataIC50:  7.39E+3nMAssay Description:Inhibition of recombinant rat Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121902(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of recombinant human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121902(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121902(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121902(CHEMBL287630 | [(S)-1-((2S,3R)-2-Benzenesulfonyl-4...)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed