BDBM50122566 4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-phenylamino)-3-cyano-quinolin-6-yl]-amide::CHEMBL113900

SMILES CC(C)N(CC#CC(=O)Nc1ccc2ncc(C#N)c(Nc3cccc(Br)c3)c2c1)C(C)C

InChI Key InChIKey=OXGRVGJNLBMVAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50122566   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122566(4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-ph...)
Affinity DataIC50:  250nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122566(4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-ph...)
Affinity DataIC50:  250nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122566(4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-ph...)
Affinity DataIC50:  320nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122566(4-Diisopropylamino-but-2-ynoic acid [4-(3-bromo-ph...)
Affinity DataIC50:  250nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed