BDBM50122574 (E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide::4-Dimethylamino-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-3-cyano-7-methoxy-quinolin-6-yl]-amide::CHEMBL114490

SMILES COc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=OEDJWFCIVDMVRU-SNAWJCMRSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50122574   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122574((E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50:  2.32E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122574((E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50:  4.49E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122574((E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50:  2.32E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122574((E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50:  2.34E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122574((E)-4-Dimethylamino-but-2-enoic acid [4-(3-chloro-...)
Affinity DataIC50:  2.32E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed