BDBM50122580 CHEMBL114392::N-[4-(3-Chloro-4-fluoro-phenylamino)-3-cyano-quinolin-6-yl]-2-morpholin-4-ylmethyl-acrylamide

SMILES Fc1ccc(Nc2c(cnc3ccc(NC(=O)C(=C)CN4CCOCC4)cc23)C#N)cc1Cl

InChI Key InChIKey=FZGMFMLMNGWHRX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50122580   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  2.70E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  2.70E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Jazan University

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50122580(CHEMBL114392 | N-[4-(3-Chloro-4-fluoro-phenylamino...)
Affinity DataIC50:  4.39E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed