BindingDB PrimarySearch

BDBM50122654 1-(4-(1-(2,6-difluorobenzyl)-5-((benzyl(methyl)amino)methyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea::1-{4-[5-[(Benzyl-methyl-amino)-methyl]-1-(2,6-difluoro-benzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidin-6-yl]-phenyl}-3-methoxy-urea::CHEMBL22055::N-[4-(3-phenyl-5-(N-benzyl-N-methyl-aminomethyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl]-N'-methoxyurea::TAK-013::sufugolix

SMILES: CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c2c1CN(C)Cc1ccccc1

InChI Key: InChIKey=UCQSBGOFELXYIN-UHFFFAOYSA-N

Data: 1 KI 98 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 99 hits for monomerid = 50122654
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	23.4	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Rat)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rat)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
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Gonadotropin-releasing hormone receptor (Rhesus macaque)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Human)	BDBM50122654 (sufugolix \| TAK-013 \| 1-{4-[5-[(Benzyl-methyl-amin...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
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