BDBM50122806 3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indol-3-yl]-piperidin-1-yl}-propionitrile::CHEMBL317333

SMILES Fc1ccc(cc1)-n1cc(C2CCN(CCC#N)CC2)c2cc(ccc12)-c1ncccn1

InChI Key InChIKey=ALBWWALSEOWKRA-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50122806   

TargetAlpha-1A adrenergic receptor(Bovine)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Golden hamster)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  67nMAssay Description:Ability to displace [3H]5-CT (2.0 nM) from HeLa cells of human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  200nMAssay Description:Ability to displace [3H]5-CT (1.5 nM) from HeLa cells of human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]spiperone (0.5 nM) from rat corpus striatum dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]ketanserin (0.5 nM) from rat cerebral cortex 5-hydroxytryptamine 2A receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  680nMAssay Description:Ability to displace [3H]spiperone (0.3 nM) from CHO cells of human Dopamine receptor D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  3.00E+3nMAssay Description:Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi: >4.20E+3nMAssay Description:Ability to displace [3H]mesulergine (0.5 nM) from CHO cells of human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50122806(3-{4-[1-(4-Fluoro-phenyl)-5-pyrimidin-2-yl-1H-indo...)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed