BDBM50123626 (S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol::CHEMBL1303::Neupro::ROTIGOTINE

SMILES CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1

InChI Key InChIKey=KFQYTPMOWPVWEJ-INIZCTEOSA-N

Data  8 KI  4 EC50

PDB links: 5 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50123626   

TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity was evaluated by calculating competition for [3H]N-0437 binding on Dopamine receptor D2L of CHO K-1 cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  0.0600nMAssay Description:In vitro binding affinity at human Dopamine receptor D2 expressed in CHO K1 cells was measured by its ability to displace [3H]- N-0437More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity at human Dopamine receptor D3 expressed in CHO K1 cells was measured by its ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  4nMAssay Description:Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells.More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(BOVINE)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  15nMAssay Description:Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  20nMAssay Description:Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D2L of CHO K-1 cells.More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  55nMAssay Description:Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells.More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(BOVINE)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  500nMAssay Description:Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 minsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataEC50:  4.10nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50123626((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataEC50:  4.40nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair