BDBM50124535 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE::5-(4'-amino-5',8'-difluoro-1'H-spiro[piperidine-4,2'-quinazoline]-1-ylcarbonyl)picolinonitrile::5-(4-Amino-5,8-difluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carbonyl)pyridine-2-carbonitrile, 3::5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]pyridine-2-carbonitrile::5-[4'-amino-5',8'-difluorospiro[hexahydropyridine-4,2'-(1',2'-dihydroquinazoline)]-1-ylcarbonyl]-2-pyridinecarbonitrile::AR-C102222::CHEMBL447183

SMILES: c1cc(ncc1C(=O)N2CCC3(CC2)Nc4c(ccc(c4C(=N3)N)F)F)C#N

InChI Key: InChIKey=GIZYIOOBBUHOBS-UHFFFAOYSA-N

Data: 17 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50124535   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
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Nitric oxide synthase, brain (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	741	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	7.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	740	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	790	n/a	n/a	n/a	n/a	7.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Human)	BDBM50124535 (5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidin...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.0	37
TBA									Citation and Details
					More data for this Ligand-Target Pair