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BDBM50124712 CHEMBL3622931

SMILES: COc1cc(Nc2nccc(n2)-n2cc(C)c(CN(C)C)c2)cc(OC)c1OC

InChI Key: InChIKey=JINKHEXGOBBTJS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50124712   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50124712
PNG
(CHEMBL3622931)
Show SMILES COc1cc(Nc2nccc(n2)-n2cc(C)c(CN(C)C)c2)cc(OC)c1OC
Show InChI InChI=1S/C21H27N5O3/c1-14-11-26(13-15(14)12-25(2)3)19-7-8-22-21(24-19)23-16-9-17(27-4)20(29-6)18(10-16)28-5/h7-11,13H,12H2,1-6H3,(H,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 72n/an/an/an/an/a25



Kangwon National University

Curated by ChEMBL


Assay Description
Inhibition of purified full-length human SYK pre-incubated for 30 mins at room temperature before Ulight-TK peptide substrate addition and measured 1...


Bioorg Med Chem Lett 25: 4441-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.011
BindingDB Entry DOI: 10.7270/Q22Z17BN
More data for this
Ligand-Target Pair