BindingDB logo
myBDB logout

BDBM50125654 (2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3-fluoro-phenyl)-acetylamino]-4-methyl-pentanoylamino}-2-hydroxy-butyric acid ethyl ester::CHEMBL283326

SMILES: CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cccc(F)c1

InChI Key: InChIKey=BYMXTSNEMIVBJD-WPFOTENUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50125654   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2


(Homo sapiens (Human))
BDBM50125654
PNG
((2R,3S)-4-Cyclohexyl-3-{(S)-2-[2-(3-fluoro-phenyl)...)
Show SMILES CCOC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cccc(F)c1
Show InChI InChI=1S/C26H39FN2O5/c1-4-34-26(33)24(31)21(15-18-9-6-5-7-10-18)29-25(32)22(13-17(2)3)28-23(30)16-19-11-8-12-20(27)14-19/h8,11-12,14,17-18,21-22,24,31H,4-7,9-10,13,15-16H2,1-3H3,(H,28,30)(H,29,32)/t21-,22-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 920n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.


Bioorg Med Chem Lett 13: 1203-6 (2003)


Article DOI: 10.1016/s0960-894x(02)01058-2
BindingDB Entry DOI: 10.7270/Q279442Z
More data for this
Ligand-Target Pair