BDBM50126039 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pentyl-phenyl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24048

SMILES CCCCCc1ccc(cc1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12

InChI Key InChIKey=RLZPEQLIWYHFHH-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50126039   

LigandPNGBDBM50126039(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pe...)
Affinity DataEC50:  3.80nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126039(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50126039(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pe...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed