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BDBM50126222 CHEMBL28034::{4-[9-(2,2,2-Trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-phosphonic acid bis-[3-(6-methyl-pyridin-2-yl)-propyl] ester

SMILES: Cc1cccc(CCCOP(=O)(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc23)OCCCc2cccc(C)n2)n1

InChI Key: InChIKey=AGWYBRTZZKJKPD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126222   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microsomal triglyceride transfer protein large subunit


(Bos taurus)
BDBM50126222
PNG
(CHEMBL28034 | {4-[9-(2,2,2-Trifluoro-ethylcarbamoy...)
Show SMILES Cc1cccc(CCCOP(=O)(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc23)OCCCc2cccc(C)n2)n1
Show InChI InChI=1S/C38H43F3N3O4P/c1-28-13-9-15-30(43-28)17-11-24-47-49(46,48-25-12-18-31-16-10-14-29(2)44-31)26-8-7-23-37(36(45)42-27-38(39,40)41)34-21-5-3-19-32(34)33-20-4-6-22-35(33)37/h3-6,9-10,13-16,19-22H,7-8,11-12,17-18,23-27H2,1-2H3,(H,42,45)
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Similars

Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against microsomal triglyceride transfer protein (MTP)


Bioorg Med Chem Lett 13: 1337-40 (2003)


Article DOI: 10.1016/s0960-894x(03)00116-1
BindingDB Entry DOI: 10.7270/Q2NC60K6
More data for this
Ligand-Target Pair