BDBM50126454 (6R,12aR)-2-((R)-1-Benzyl-pyrrolidin-3-yl)-6-(3,4-dimethoxy-phenyl)-2,3,6,7,12,12a-hexahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione::CHEMBL284745
SMILES COc1ccc(cc1OC)[C@H]1N2[C@H](Cc3c1[nH]c1ccccc31)C(=O)N(CC2=O)[C@@H]1CCN(Cc2ccccc2)C1
InChI Key InChIKey=HNZPKXUYPCLKGI-YYKZIPJASA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50126454
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) obtained from human corpus cavernosum tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of bovine PDE5 after 24 hrs by time-resolved fluorescence resonance energy transfer assayMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expressionMore data for this Ligand-Target Pair