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BDBM50126564 4-{5-[3-Benzyl-2,4-dioxo-5-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-imidazolidin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL32863

SMILES: [#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])n(-[#6]-c2ccccc2)c(=O)n1-[#6]-c1cncn1-[#6]-c1ccc(cc1)C#N

InChI Key: InChIKey=JNEDKPBHLDVQGB-XVGJRRPCSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50126564   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50126564
PNG
(4-{5-[3-Benzyl-2,4-dioxo-5-((2E,6E)-3,7,11-trimeth...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\Cc1c(O)n(Cc2ccccc2)c(=O)n1Cc1cncn1Cc1ccc(cc1)C#N
Show InChI InChI=1S/C37H43N5O2/c1-28(2)10-8-11-29(3)12-9-13-30(4)16-21-35-36(43)42(25-32-14-6-5-7-15-32)37(44)41(35)26-34-23-39-27-40(34)24-33-19-17-31(22-38)18-20-33/h5-7,10,12,14-20,23,27,43H,8-9,11,13,21,24-26H2,1-4H3/b29-12+,30-16+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
In vitro inhibition of bovine Farnesyl transferase


Bioorg Med Chem Lett 13: 1459-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00171-9
BindingDB Entry DOI: 10.7270/Q2TX3DSS
More data for this
Ligand-Target Pair