BindingDB logo
myBDB logout

BDBM50128796 4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-pyridin-2-yl]-benzene-1,2-diol::CHEMBL82402

SMILES: Oc1ccc(cc1O)[C@@H]1[C@H](C(C=CN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O

InChI Key: InChIKey=YSZZUTNFHHXGEX-ZPUYXXQXSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50128796   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM50128796
PNG
(4-[4-(2-Bromo-phenyl)-3-nitro-1-pyridin-3-ylmethyl...)
Show SMILES Oc1ccc(cc1O)[C@@H]1[C@H](C(C=CN1Cc1cccnc1)c1ccccc1Br)[N+]([O-])=O
Show InChI InChI=1S/C23H20BrN3O4/c24-19-6-2-1-5-17(19)18-9-11-26(14-15-4-3-10-25-13-15)22(23(18)27(30)31)16-7-8-20(28)21(29)12-16/h1-13,18,22-23,28-29H,14H2/t18?,22-,23+/m1/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of bovine brain farnesyltransferase (FTase) farnesylation of viral K-Ras


J Med Chem 46: 2467-73 (2003)


Article DOI: 10.1021/jm020522k
BindingDB Entry DOI: 10.7270/Q2RN3775
More data for this
Ligand-Target Pair