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BDBM50129648 3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxylic acid thiazol-2-ylamide::CHEMBL328350

SMILES: [#6]\[#6](-[#6])=[#6]/[#6]-[#6](=O)-[#7]-c1cccnc1-[#6](=O)-[#7]-c1nccs1

InChI Key: InChIKey=QLSMZADEWAIARS-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50129648   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129648
PNG
(3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxyl...)
Show SMILES CC(C)=CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H16N4O2S/c1-10(2)5-6-12(20)18-11-4-3-7-16-13(11)14(21)19-15-17-8-9-22-15/h3-5,7-9H,6H2,1-2H3,(H,18,20)(H,17,19,21)
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CHEMBL
PC cid
PC sid
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Similars

Article
PubMed
n/an/a 1.40E+5n/an/an/an/an/an/a



Graduate School of the Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)


Bioorg Med Chem Lett 15: 3732-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.055
BindingDB Entry DOI: 10.7270/Q2T1534B
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129648
PNG
(3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxyl...)
Show SMILES CC(C)=CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H16N4O2S/c1-10(2)5-6-12(20)18-11-4-3-7-16-13(11)14(21)19-15-17-8-9-22-15/h3-5,7-9H,6H2,1-2H3,(H,18,20)(H,17,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 1 from Escherichia coli


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair
Methionine aminopeptidase 1


(Saccharomyces cerevisiae)
BDBM50129648
PNG
(3-(4-Methyl-pent-3-enoylamino)-pyridine-2-carboxyl...)
Show SMILES CC(C)=CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H16N4O2S/c1-10(2)5-6-12(20)18-11-4-3-7-16-13(11)14(21)19-15-17-8-9-22-15/h3-5,7-9H,6H2,1-2H3,(H,18,20)(H,17,19,21)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against type I methionine aminopeptidase from Saccharomyces cerevisiae


J Med Chem 46: 2631-40 (2003)


Article DOI: 10.1021/jm0300532
BindingDB Entry DOI: 10.7270/Q2CF9QTC
More data for this
Ligand-Target Pair