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BDBM50130516 (+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-3,5-dicarboxylic acid::(3aS,5R,6aS)-5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-3,5-dicarboxylic acid::5-Amino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-3,5-dicarboxylic acid::CHEMBL421402

SMILES: N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O

InChI Key: InChIKey=NTVFQKSMRLANLZ-PDJPSNROSA-N

Data: 5 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50130516   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(RAT)
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.40E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibitory constant of the compound against cloned rat Metabotropic glutamate receptor 1 expressed in Chinese Hamster Ovary (CHO) cells


J Med Chem 46: 3102-8 (2003)


Article DOI: 10.1021/jm0308085
BindingDB Entry DOI: 10.7270/Q2X34WWZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9.50E+4n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR1 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
6.40E+5n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibitory constant of the compound against cloned rat Metabotropic glutamate receptor 5 expressed in Chinese Hamster Ovary (CHO) cells


J Med Chem 46: 3102-8 (2003)


Article DOI: 10.1021/jm0308085
BindingDB Entry DOI: 10.7270/Q2X34WWZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Binding affinity for mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Inhibitory constant of the compound against cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells


J Med Chem 46: 3102-8 (2003)


Article DOI: 10.1021/jm0308085
BindingDB Entry DOI: 10.7270/Q2X34WWZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Activity of the compound tested at cloned rat Metabotropic glutamate receptor 4 expressed in Chinese Hamster Ovary (CHO) cells


J Med Chem 46: 3102-8 (2003)


Article DOI: 10.1021/jm0308085
BindingDB Entry DOI: 10.7270/Q2X34WWZ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50130516
PNG
((+/-)-(3aS*,5R*,6aS*)-5-amino-4,5,6,6a-tetrahydro-...)
Show SMILES N[C@]1(C[C@@H]2ON=C([C@@H]2C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N2O5/c9-8(7(13)14)1-3-4(2-8)15-10-5(3)6(11)12/h3-4H,1-2,9H2,(H,11,12)(H,13,14)/t3-,4+,8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+6n/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Effective concentration against mGluR4 receptor expressed in CHO cells


J Med Chem 48: 6315-25 (2005)


Article DOI: 10.1021/jm0504499
BindingDB Entry DOI: 10.7270/Q2PC31X8
More data for this
Ligand-Target Pair