BDBM50130608 2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-phenoxy)-phenyl]-pyridin-3-ylmethyl-amide::CHEMBL108939::LY-487379::US10800776, Example LY487379

SMILES COc1ccccc1Oc1ccc(cc1)N(Cc1cccnc1)S(=O)(=O)CC(F)(F)F

InChI Key InChIKey=ALMACYDZFBMGOR-UHFFFAOYSA-N

Data  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50130608   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  270nMAssay Description:Effective concentration of the compound against Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Ability of the compound to displace [3H]-LY-341,495 at glutamate-site on Metabotropic glutamate receptor 2; No significant displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  230nMAssay Description:Experimental materials: HEK/mGluR2 cell line (human GluR2 transfected HEK cell line), DMEM (FBS) medium, positive control LY487379 (purchased from si...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Effective concentration for binding to human metabotropic glutamate receptor 2 as determined by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed