BindingDB PrimarySearch

BDBM50130648 CHEMBL432798::N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide

SMILES: CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1

InChI Key: InChIKey=CJKGORBZVWDVRY-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50130648
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tu£bingen Curated by ChEMBL					Assay Description Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay				J Med Chem 54: 3283-97 (2011) Article DOI: 10.1021/jm101623p BindingDB Entry DOI: 10.7270/Q2W959H4
Eberhard-Karls-University Tu£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibitory activity against TNF-alpha release in PBM cells				J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8
Eberhard-Karls-University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibition of p38-related TNF-alpha release by whole blood cells at 10 e-4 to 10 e-8 M				J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8
Eberhard-Karls-University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
c-a-i-r biosciences GmbH Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in HEK293 cells by patch clamp method				J Med Chem 60: 5290-5305 (2017) Article DOI: 10.1021/acs.jmedchem.6b01647 BindingDB Entry DOI: 10.7270/Q22F7QV8
c-a-i-r biosciences GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibitory activity against induction of IL-1-beta release in PBMCs				J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8
Eberhard-Karls-University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentration				J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8
Eberhard-Karls-University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase p38 (Homo sapiens (Human))	BDBM50130648 (CHEMBL432798 \| N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University T£bingen Curated by ChEMBL					Assay Description Inhibition of p38-related IL1-beta release by whole blood cells at 10 e-4 to 10 e-8 M				J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8
Eberhard-Karls-University T£bingen Curated by ChEMBL					More data for this Ligand-Target Pair