BDBM50130648 CHEMBL432798::N-{4-[5-(4-Fluoro-phenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide
SMILES: CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1
InChI Key: InChIKey=CJKGORBZVWDVRY-UHFFFAOYSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tu£bingen Curated by ChEMBL | Assay Description Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay | J Med Chem 54: 3283-97 (2011) Article DOI: 10.1021/jm101623p BindingDB Entry DOI: 10.7270/Q2W959H4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University T£bingen Curated by ChEMBL | Assay Description Inhibitory activity against TNF-alpha release in PBM cells | J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University T£bingen Curated by ChEMBL | Assay Description Inhibition of p38-related TNF-alpha release by whole blood cells at 10 e-4 to 10 e-8 M | J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
c-a-i-r biosciences GmbH Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK293 cells by patch clamp method | J Med Chem 60: 5290-5305 (2017) Article DOI: 10.1021/acs.jmedchem.6b01647 BindingDB Entry DOI: 10.7270/Q22F7QV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University T£bingen Curated by ChEMBL | Assay Description Inhibitory activity against induction of IL-1-beta release in PBMCs | J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University T£bingen Curated by ChEMBL | Assay Description Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentration | J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Homo sapiens (Human)) | BDBM50130648![]() (CHEMBL432798 | N-{4-[5-(4-Fluoro-phenyl)-3-methyl-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University T£bingen Curated by ChEMBL | Assay Description Inhibition of p38-related IL1-beta release by whole blood cells at 10 e-4 to 10 e-8 M | J Med Chem 46: 3230-44 (2003) Article DOI: 10.1021/jm030766k BindingDB Entry DOI: 10.7270/Q20K2CB8 | |||||||||||
More data for this Ligand-Target Pair |