BDBM50131995 (E)-3-(4-hydroxybenzylidene)indolin-2-one::3-(4-Hydroxy-benzylidene)-1,3-dihydro-indol-2-one::3-(4-hydroxybenzylidene)indolin-2-one::CHEMBL103307

SMILES Oc1ccc(\C=C2\C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=PLAOAGFXNCEZMZ-UKTHLTGXSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50131995   

TargetVascular endothelial growth factor receptor 2(Mus musculus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: >4.20E+4nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human GSK3beta (636 to 661 residues) assessed as reduction in human muscle glycogen synthase type 1 fragment phosphorylatio...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of porcine brain tubulin polymerization by GTP-induced assemblyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50131995((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed