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BDBM50132442 3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide::CHEMBL105421

SMILES: COc1ccc2n(C)cc(CC3C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1

InChI Key: InChIKey=YUFXVKVATYTTCX-UHFFFAOYNA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50132442   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50132442
PNG
(3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2...)
Show SMILES COc1ccc2n(C)cc(CC3C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
Show InChI InChI=1/C19H19N3O4S/c1-22-10-11(14-8-12(26-2)3-6-18(14)22)7-16-15-9-13(27(20,24)25)4-5-17(15)21-19(16)23/h3-6,8-10,16H,7H2,1-2H3,(H,21,23)(H2,20,24,25)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



Aventis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis


Bioorg Med Chem Lett 13: 3111-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00658-9
BindingDB Entry DOI: 10.7270/Q2ZG6SS7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50132442
PNG
(3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2...)
Show SMILES COc1ccc2n(C)cc(CC3C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
Show InChI InChI=1/C19H19N3O4S/c1-22-10-11(14-8-12(26-2)3-6-18(14)22)7-16-15-9-13(27(20,24)25)4-5-17(15)21-19(16)23/h3-6,8-10,16H,7H2,1-2H3,(H,21,23)(H2,20,24,25)
PDB
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



Punjabi University

Curated by ChEMBL


Assay Description
Inhibition of spleen tyrosine kinase (unknown origin)


Eur J Med Chem 67: 434-46 (2013)


Article DOI: 10.1016/j.ejmech.2013.04.070
BindingDB Entry DOI: 10.7270/Q2Z039JB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50132442
PNG
(3-(5-Methoxy-1-methyl-1H-indol-3-ylmethyl)-2-oxo-2...)
Show SMILES COc1ccc2n(C)cc(CC3C(=O)Nc4ccc(cc34)S(N)(=O)=O)c2c1
Show InChI InChI=1/C19H19N3O4S/c1-22-10-11(14-8-12(26-2)3-6-18(14)22)7-16-15-9-13(27(20,24)25)4-5-17(15)21-19(16)23/h3-6,8-10,16H,7H2,1-2H3,(H,21,23)(H2,20,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.10E+3n/an/an/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair