BDBM50132994 2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-pyridine::CHEMBL125738

SMILES Cc1cccc(n1)-c1n[nH]cc1-c1ccc(Cl)cc1

InChI Key InChIKey=HTVAFUKFRNIMHR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132994   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  421nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  551nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  57nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50: >2.00E+4nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed