BDBM50133625 1-Benzyl-5-chloro-1H-indole-2,3-dione::CHEMBL336693

SMILES Clc1ccc2N(Cc3ccccc3)C(=O)C(=O)c2c1

InChI Key InChIKey=CCPOUFJZMAONLI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50133625   

TargetFalcipain 2(Plasmodium falciparum)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)
Affinity DataIC50:  4.69E+4nMAssay Description:Inhibitory activity was tested against Falcipain-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of Cape Town

Curated by ChEMBL
LigandPNGBDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibitory activity against the Trypanosoma cruzi cysteine protease cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of full length human ALDH3A1 expressed in Escherichia coli BL21 (DE3) using benzaldehyde as substrate preincubated for 2 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed