BDBM50133864 CHEMBL2139947::US10251893, Compound 59

SMILES Cc1cc(ccn1)-c1ccc(CC(=O)Nc2ccc(cc2)-c2cccnc2)cc1

InChI Key InChIKey=KHZOJCQBHJUJFY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50133864   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50133864(CHEMBL2139947 | US10251893, Compound 59)
Affinity DataIC50:  0.0740nMAssay Description:Inhibition of porcupine activity (unknown origin) expressed in human HT1080 cells assessed as suppression of Wnt3A-mediated super top flash activity ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50133864(CHEMBL2139947 | US10251893, Compound 59)
Affinity DataIC50: <1nMAssay Description:Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50133864(CHEMBL2139947 | US10251893, Compound 59)
Affinity DataIC50: <0.110nMAssay Description:Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...More data for this Ligand-Target Pair
In DepthDetails US Patent