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BDBM50133999 CHEMBL345035::N,N'-(9-(2-aminophenylamino)acridine-2,7-diyl)bis(3-(pyrrolidin-1-yl)propanamide)::N-[9-(2-Amino-phenylamino)-7-(3-pyrrolidin-1-yl-propionylamino)-acridin-2-yl]-3-pyrrolidin-1-yl-propionamide

SMILES: Nc1ccccc1Nc1c2cc(NC(=O)CCN3CCCC3)ccc2nc2ccc(NC(=O)CCN3CCCC3)cc12

InChI Key: InChIKey=ZKZZIOIEKVPIQX-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50133999   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50133999
PNG
(CHEMBL345035 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2cc(NC(=O)CCN3CCCC3)ccc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-30(27)38-33-25-21-23(35-31(41)13-19-39-15-3-4-16-39)9-11-28(25)37-29-12-10-24(22-26(29)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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PC sid
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Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Central University of Las Villas

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human A2780 cells by TRAP assay


Eur J Med Chem 44: 4826-40 (2009)


Article DOI: 10.1016/j.ejmech.2009.07.029
BindingDB Entry DOI: 10.7270/Q20R9PHM
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50133999
PNG
(CHEMBL345035 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2cc(NC(=O)CCN3CCCC3)ccc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-30(27)38-33-25-21-23(35-31(41)13-19-39-15-3-4-16-39)9-11-28(25)37-29-12-10-24(22-26(29)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 170n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair