BDBM50134030 9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido) acridine::CHEMBL336434::N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3,6-diyl)bis(3-pyrrolidin-1-ylpropanamide)

SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1

InChI Key InChIKey=RKPYSYRMIXRZJT-UHFFFAOYSA-N

Data  7 IC50  5 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50134030   

TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataEC50:  115nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataEC50:  113nMAssay Description:Effective concentration against telomerase by TRAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataEC50:  113nMAssay Description:Inhibition of telomerase activity from human A2780 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataEC50:  6.30E+3nMAssay Description:Inhibition of telomerase (unknown origin) by TRAP-LIG assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human telomerase in A549 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of telomerase in human A2780 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataEC50:  120nMAssay Description:Inhibition of human telomerase by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of London

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  830nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtection of telomeres protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed