BDBM50134431 CHEMBL3747181

SMILES: CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O

InChI Key: InChIKey=WGGRXSZLNZHDJO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50134431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50134431 (CHEMBL3747181) Show SMILES CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C17H17Cl2N5O3S/c1-8(2)13-16-21-7-12(14(20)25)15(24(16)23-17(13)28(3,26)27)22-11-5-9(18)4-10(19)6-11/h4-8,22H,1-3H3,(H2,20,25)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	507	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of PDE4 in human SHSY-5Y cells assessed as suppression of cAMP hydrolysis by HTRF assay in presence of dye d2 labelled cAMP				Bioorg Med Chem Lett 26: 454-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50134431 (CHEMBL3747181) Show SMILES CC(C)c1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc12)C(N)=O)S(C)(=O)=O Show InChI InChI=1S/C17H17Cl2N5O3S/c1-8(2)13-16-21-7-12(14(20)25)15(24(16)23-17(13)28(3,26)27)22-11-5-9(18)4-10(19)6-11/h4-8,22H,1-3H3,(H2,20,25)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Research Center Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay				Bioorg Med Chem Lett 26: 454-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.093 BindingDB Entry DOI: 10.7270/Q2X92D4M
					More data for this Ligand-Target Pair