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BDBM50134843 4-(1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide::CHEMBL146114

SMILES: Cn1ncc2c(ncnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1

InChI Key: InChIKey=YMPLJTQXVDRIBX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50134843   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134843
PNG
(4-(1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-pipe...)
Show SMILES Cn1ncc2c(ncnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H23N7O2/c1-28-21-20(15-26-28)22(25-16-24-21)29-11-13-30(14-12-29)23(31)27-17-7-9-19(10-8-17)32-18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3,(H,27,31)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
BindingDB Entry DOI: 10.7270/Q2X929PJ
More data for this
Ligand-Target Pair