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BDBM50135342 CHEMBL340186::{5-[(Cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethyl-thiazol-2-yl}-(2,6-diethyl-phenyl)-amine

SMILES: CCCN(CC1CC1)Cc1sc(Nc2c(CC)cccc2CC)nc1C(F)(F)F

InChI Key: InChIKey=WIOZEXBDJKNFCC-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50135342   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50135342
PNG
(CHEMBL340186 | {5-[(Cyclopropylmethyl-propyl-amino...)
Show SMILES CCCN(CC1CC1)Cc1sc(Nc2c(CC)cccc2CC)nc1C(F)(F)F
Show InChI InChI=1S/C22H30F3N3S/c1-4-12-28(13-15-10-11-15)14-18-20(22(23,24)25)27-21(29-18)26-19-16(5-2)8-7-9-17(19)6-3/h7-9,15H,4-6,10-14H2,1-3H3,(H,26,27)
PDB
MMDB

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Similars

Article
PubMed
>4.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity by displacement of [125I]-Tyr-o-CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cel...


Bioorg Med Chem Lett 13: 3997-4000 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.055
BindingDB Entry DOI: 10.7270/Q2MW2GJW
More data for this
Ligand-Target Pair