BDBM50135415 3-((R)-5-{4-[(Biphenyl-2-carbonyl)-amino]-benzoyl}-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-2-yl)-propionic acid::CHEMBL334777

SMILES OC(=O)CC[C@@H]1CCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc2S1

InChI Key InChIKey=BVJZPAJDRJEDNQ-RUZDIDTESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50135415   

TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50135415(3-((R)-5-{4-[(Biphenyl-2-carbonyl)-amino]-benzoyl}...)
Affinity DataIC50:  314nMAssay Description:Ability of the compound to displace [3H]-arginine vasopressin in cloned human V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50135415(3-((R)-5-{4-[(Biphenyl-2-carbonyl)-amino]-benzoyl}...)
Affinity DataIC50:  4.63E+3nMAssay Description:Inhibition of vasopressin induced cAMP accumulation in human V2 receptor expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50135415(3-((R)-5-{4-[(Biphenyl-2-carbonyl)-amino]-benzoyl}...)
Affinity DataIC50:  16nMAssay Description:Inhibition of vasopressin induced cAMP accumulation in human V2 receptor expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50135415(3-((R)-5-{4-[(Biphenyl-2-carbonyl)-amino]-benzoyl}...)
Affinity DataIC50:  40nMAssay Description:Inhibition of vasopressin induced cAMP accumulation in human V2 receptor expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed