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BDBM50135904 7-(4-Dimethylamino-phenyl)-5,6-bis-(4-isopropyl-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine::CHEMBL151079

SMILES: CC(C)c1ccc(cc1)-c1c(nc2ncnc(N)c2c1-c1ccc(cc1)C(C)C)-c1ccc(cc1)N(C)C

InChI Key: InChIKey=XRMDQDPTBZOBAD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50135904   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine Kinase (AK)


(Rattus norvegicus (rat))
BDBM50135904
PNG
(7-(4-Dimethylamino-phenyl)-5,6-bis-(4-isopropyl-ph...)
Show SMILES CC(C)c1ccc(cc1)-c1c(nc2ncnc(N)c2c1-c1ccc(cc1)C(C)C)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C33H35N5/c1-20(2)22-7-11-24(12-8-22)28-29(25-13-9-23(10-14-25)21(3)4)31(26-15-17-27(18-16-26)38(5)6)37-33-30(28)32(34)35-19-36-33/h7-21H,1-6H3,(H2,34,35,36,37)
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PC cid
PC sid
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Article
PubMed
n/an/a 6.70n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition adenosine kinase activity in rat brain in vitro


J Med Chem 46: 5249-57 (2003)

More data for this
Ligand-Target Pair
Adenosine kinase


(Homo sapiens)
BDBM50135904
PNG
(7-(4-Dimethylamino-phenyl)-5,6-bis-(4-isopropyl-ph...)
Show SMILES CC(C)c1ccc(cc1)-c1c(nc2ncnc(N)c2c1-c1ccc(cc1)C(C)C)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C33H35N5/c1-20(2)22-7-11-24(12-8-22)28-29(25-13-9-23(10-14-25)21(3)4)31(26-15-17-27(18-16-26)38(5)6)37-33-30(28)32(34)35-19-36-33/h7-21H,1-6H3,(H2,34,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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antibodypedia
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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of adenosine kinase activity in IMR-32 human neuroblastoma cells


J Med Chem 46: 5249-57 (2003)

More data for this
Ligand-Target Pair