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BDBM50136156 4-[(3-Chloro-2-methyl-phenoxy)-phenyl-methyl]-piperidine::CHEMBL153533

SMILES: Cc1c(Cl)cccc1OC(C1CCNCC1)c1ccccc1

InChI Key: InChIKey=ZBGZSYCCKZNBEE-UHFFFAOYSA-N

Data: 1 KI  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50136156   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine transporters; Norepinephrine & serotonin


(Rattus norvegicus (rat))
BDBM50136156
PNG
(4-[(3-Chloro-2-methyl-phenoxy)-phenyl-methyl]-pipe...)
Show SMILES Cc1c(Cl)cccc1OC(C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C19H22ClNO/c1-14-17(20)8-5-9-18(14)22-19(15-6-3-2-4-7-15)16-10-12-21-13-11-16/h2-9,16,19,21H,10-13H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12.2n/an/an/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats


J Med Chem 46: 5512-32 (2003)


Article DOI: 10.1021/jm0309349
BindingDB Entry DOI: 10.7270/Q2QF8TMN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50136156
PNG
(4-[(3-Chloro-2-methyl-phenoxy)-phenyl-methyl]-pipe...)
Show SMILES Cc1c(Cl)cccc1OC(C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C19H22ClNO/c1-14-17(20)8-5-9-18(14)22-19(15-6-3-2-4-7-15)16-10-12-21-13-11-16/h2-9,16,19,21H,10-13H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranes


J Med Chem 46: 5512-32 (2003)


Article DOI: 10.1021/jm0309349
BindingDB Entry DOI: 10.7270/Q2QF8TMN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50136156
PNG
(4-[(3-Chloro-2-methyl-phenoxy)-phenyl-methyl]-pipe...)
Show SMILES Cc1c(Cl)cccc1OC(C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C19H22ClNO/c1-14-17(20)8-5-9-18(14)22-19(15-6-3-2-4-7-15)16-10-12-21-13-11-16/h2-9,16,19,21H,10-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



FAES FARMA S A

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranes


J Med Chem 46: 5512-32 (2003)


Article DOI: 10.1021/jm0309349
BindingDB Entry DOI: 10.7270/Q2QF8TMN
More data for this
Ligand-Target Pair