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BDBM50136651 ({2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2-yl]-5-propyl-1H-imidazole-4-carbonyl}-amino)-acetic acid methyl ester::CHEMBL344879

SMILES: CCCc1nc([nH]c1C(=O)NCC(=O)OC)[C@@H]1Cc2ccccc2N1C(=O)CN

InChI Key: InChIKey=NBAJFCLHQDLSIK-HNNXBMFYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50136651   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tripeptidyl aminopeptidase


(Rattus norvegicus)
BDBM50136651
PNG
(({2-[(S)-1-(2-Amino-acetyl)-2,3-dihydro-1H-indol-2...)
Show SMILES CCCc1nc([nH]c1C(=O)NCC(=O)OC)[C@@H]1Cc2ccccc2N1C(=O)CN
Show InChI InChI=1S/C20H25N5O4/c1-3-6-13-18(20(28)22-11-17(27)29-2)24-19(23-13)15-9-12-7-4-5-8-14(12)25(15)16(26)10-21/h4-5,7-8,15H,3,6,9-11,21H2,1-2H3,(H,22,28)(H,23,24)/t15-/m0/s1
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PC sid
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Similars

Article
PubMed
n/an/a 135n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Tripeptidyl-peptidase II purified from a rat liver post-lysosomal fraction.


Bioorg Med Chem Lett 13: 4467-71 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.014
BindingDB Entry DOI: 10.7270/Q289159P
More data for this
Ligand-Target Pair