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BDBM50137303 2-(3'-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-cyclopent-1-enecarboxylic acid::CHEMBL351786

SMILES: CCOc1cccc(c1)-c1cc(F)c(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1

InChI Key: InChIKey=KOEKNDUNWSNVCY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50137303   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50137303
PNG
(2-(3'-Ethoxy-3,5-difluoro-biphenyl-4-ylcarbamoyl)-...)
Show SMILES CCOc1cccc(c1)-c1cc(F)c(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1
Show InChI InChI=1S/C21H19F2NO4/c1-2-28-14-6-3-5-12(9-14)13-10-17(22)19(18(23)11-13)24-20(25)15-7-4-8-16(15)21(26)27/h3,5-6,9-11H,2,4,7-8H2,1H3,(H,24,25)(H,26,27)
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Article
PubMed
n/an/a 17n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human dihydroorotate dehydrogenase (DHODH)


Bioorg Med Chem Lett 14: 55-8 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.021
BindingDB Entry DOI: 10.7270/Q2XS5TS2
More data for this
Ligand-Target Pair