BDBM50138040 (biphenyl-3-ylamino)methylenediphosphonic acid::BPH-218::CHEMBL55371::[(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid

SMILES OP(O)(=O)C(Nc1cccc(c1)-c1ccccc1)P(O)(O)=O

InChI Key InChIKey=IXFMBXNLOHKCPT-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50138040   

TargetDecaprenyl diphosphate synthase(Mycobacterium tuberculosis H37Rv)
University Of California San Diego

LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  6.30E+3nMpH: 7.5Assay Description:We screened an in-house library of 53 compounds using trans-FPP as substrate. Briefly, the condensation of IPP and GPP, FPP, or cis-FPP catalyzed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  9.37E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  7.63E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  309nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of MMP14 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  810nMAssay Description:Inhibition of Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138040((biphenyl-3-ylamino)methylenediphosphonic acid | B...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed